Thalassemia is a group of inherited blood disorders.

海贫血是一组性血液疾病。

These are diseases like sickle cell anemia or beta thalassemia.

比如镰状细胞性贫血或β海贫血。

And alpha thalassemia is caused by mutations in the alpha genes, most commonly a gene deletion.

α海贫血是由α基因变异引起，最常见原因是基因缺失。

Usually, patients with mild thalassemia don't need treatment, while patients with severe thalassemia are treated with blood transfusions.

常情况下，轻度海贫血无需治疗，重度贫患者需输血治疗。

If a person has two defective alpha genes, the person has alpha thalassemia minor, which causes mild symptoms.

如果有2个α基因异常，则会出现轻度α海贫血，会引起轻微症状。

With moderate alpha thalassemia, there may be golf-ball like RBCs, due to precipitated HbH molecules.

度α海贫血患者，由于HbH分子沉积，可见高尔夫球样红细胞。

The initial symptoms of minor and moderate alpha thalassemia are due to anemia, which include pallor, shortness of breath, and easy fatigability.

轻度和度α海贫血首发症状往往是贫血，表现为苍白、气促、乏力。

All right, as a quick recap: alpha thalassemia is an autosomal recessive disorder caused by deletion of alpha globin genes on chromosome 16.

得！快速回顾一下：α海贫血是一种常染色体隐性病，由16号染色体上α珠蛋白基因缺陷引起。

To prevent complications from an existing blood or bleeding disorder, such as sickle cell disease, thalassemia, or anaemia caused by kidney disease, haemophilia, or von Willebrand disease.

预防现有血液或出血性疾病并发症，如镰状细胞病、海贫血或由肾脏疾病、血友病或血管性血友病引起贫血。