As this fibrotic tissue builds up, it starts to compress the central veins and sinusoids.

堆积在一起纤维组织会挤压中央静脉和血窦。

But due to the periodic nature of sinusoids, these waves of different frequencies overlap in a predictable way.

但由于正弦曲线周期性，这些不同频率波以可预测重叠。

Well fibrosis is a process mediated by special cells called stellate cells, that sit between the sinusoid and hepatocyte, known as the perisinusoidal space.

纤维化过程是由星形调控；星形位于血窦和肝间，即窦周间隙。

Frequently affected organs include the liver, where the bacterial toxins damage liver sinusoids and hepatocytes, causing bilirubin to spill into the bloodstream - which clinically translates as jaundice.

肝脏是常见受累器官，菌释放毒素破坏肝窦及肝，导致胆红素释放入血液循环，在临床上表现为黄疸。

As the central veins and sinusoids become compressed and push on the fluid inside, their pressure starts to build up, leading to intrasinusoidal (or portal) hypertension, which is this higher pressure in the portal veins.

中央静脉和血窦受压导致它们中间液体也受到挤压，导致门静脉高压，即门静脉压力升高。

Here's a pretty basic layout of the basic functional unit of the liver, you've got the portal vein and hepatic artery that combine into a sinusoid, which then goes into the central vein, and these are all lined with hepatocytes.

这是一个肝脏基本功能单位简单示意图，你可以看到由门静脉和肝动脉来血液在血窦汇集，然后流入中央静脉，这些都与干相平行。