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Furthermore, PTP1B deletion significantly reduced gene expression of 3 1-adrenergic receptor subtypes, consistent with blunted constriction to phenylephrine.

此外PTP1B缺乏明显减少31-肾上腺受体亚型基因表达,与对苯福林收缩反应迟

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HPLC method for determination of phenylephrine hydrochloride, paracetamol, caffeine anhydrous,salicylamide and brompheniramine maleate in Liufenkamin tablets was established.

HPLC法测定柳酚咖敏片中盐酸去氧肾上腺素、对乙酰氨基酚、无水咖啡因、水杨酰胺、马来酸溴苯那敏的含量。

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当月 科学60秒-科学美国人

One of the most popular decongestant ingredients is phenylephrine.

减充血剂最常见成分之一是苯肾

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当月 科学60秒-科学美国人

Exactly. So, more products started using phenylephrine.

没错。于是更多的产品开始使用苯肾

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Vox

We'll make phenylephrine red because we know it leaves you congested.

我们会让苯肾的成像变红,因为我们知道它会让你充血。

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当月 科学60秒-科学美国人

And I always look to see if a decongestant like phenylephrine is in the capsule.

我总是看胶囊成分,是否含有像苯肾这样的减充血剂。

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Vox

But I didn't know there was anything wrong with phenylephrine.

但我不知道苯肾有什么问题。

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当月 科学60秒-科学美国人

So, the committee voted unanimously that oral phenylephrine is basically useless.

因此,委员会一致认为口服苯肾缓解鼻塞的功效。

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Vox

" 10 milligrams of phenylephrine works no better than a placebo."

“10 毫克苯肾的效果不比安慰剂好。”

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当月 科学60秒-科学美国人

Overall, though, if oral phenylephrine doesn't work, what should people use instead of it?

总的来说,如果口服苯肾不起作用,还有什么更好的替代品吗?

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当月 科学60秒-科学美国人

Scientists who advise the FDA recently concluded that phenylephrine, a common decongestant in cold medicines, doesn't work.

美国食品和药品管理局(FDA)的顾问科学家最近得出结论:感冒药中常见的减充血剂苯肾不起作用。

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Vox

It led to further similarly conclusive studies that phenylephrine was ineffective.

这导致了进一步类似的结论性研究,即苯肾效的。

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当月 科学60秒-科学美国人

She was on the recent FDA advisory panel earlier this month that made the decision that phenylephrine wasn't effective.

她是本月早些时候做出苯肾效决定的FDA顾问小组的专家。

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Vox

The take-home messages are oral phenylephrine is inaffective as a nasal decongestant but safe.

带回家的信息是口服苯肾作为减充血剂是效的,但安全。

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当月 科学60秒-科学美国人

Exactly. In addition to that, three trials of oral phenylephrine showed it was no better than a placebo at relieving congestion.

确实如此。除此之外,口服苯肾的三项试验表明,这种成分在缓解充血方面不比安慰剂好。

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Vox

Where nasal congestion went down after taking pseudoephedrine and went like this for a placebo and phenylephrine.

服用伪麻黄碱后鼻塞减轻,服用安慰剂和苯肾后鼻塞也减轻。

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科学快报-科学美国人Science Quickly, from SCIENTIFIC AMERICAN

They didn't review phenylephrine nasal sprays.

刘易斯:他们没有审查去氧肾鼻喷雾剂。

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Vox

They have known for decades that phenylephrine might not really work and it's just the process that's gotten in the way.

他们几十年前就知道苯肾可能没有真正起作用,只是这个过程阻碍了治疗。

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Vox

And the panelists voting, they seemed a little mystified by how we got to a point where phenylephrine took over.

小组成员投票时,他们似乎有困惑,为什么我们会走到苯肾占据主导地位的地步。

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Vox

Taken from an FDA Zoom meeting these are the votes of FDA panel members on whether phenylephrine is effective.

摘自 FDA Zoom 会议这些是 FDA 小组成员对苯肾是否有效的投票。

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当月 科学60秒-科学美国人

They didn't review phenylephrine nasal sprays. Those might still be effective since they are going right into your nose.

他们没有审查苯肾鼻腔喷雾剂的功效。这些成分可能仍然有效,因为它们直接进入了鼻腔。

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科学快报-科学美国人Science Quickly, from SCIENTIFIC AMERICAN

Fischman: Overall, though, if oral phenylephrine doesn't work, what should people use instead of it?

Fischman:不过,总的来说,如果口服去氧肾不起作用,人们应该用什么来代替它?

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