Giuseppe Remuzzi is the director of the Mario Negri Institute for pharmacological research.

朱塞佩·雷穆齐是马里奥·内格里理研究所主任。

Amazingly, this pharmacological extinction method has been shown to be very effective with alcohol.

令人吃惊的是，“理灭绝”法来治疗酒精上瘾也非常有效。

Coronary steal syndrome is diagnosed when the electrocardiogram shows an ST-segment depression during a pharmacological cardiac stress test.

冠状动脉窃血综合征，通常在物心脏负荷试验程中心电图上出现ST段压低时作出诊断。

That is useful information, for it suggests where a pharmacological assault on the disease might best be directed.

这是很有价值的信息，能判断在哪里能直达病。

However, Dr. David Sinclair, the person who this method has been credited to, refers to it as pharmacological extinction.

，该方法的发明者——David Sinclair 博士——将这种方法称为“理灭绝”。

Funding is readily available to research pharmacological solutions.

研究理学解决方案的资金很容易获得。

Coronary steal syndrome is a finding observed during a pharmacological cardiac stress test, which is used to diagnose coronary artery disease.

冠状动脉窃血综合征是在一次物心脏负荷试验中被发现的；该类试验本于诊断冠状动脉疾病。

The concept to explore here is called " pharmacological extinction, " but before we get into that, let's talk about pesto.

有一个医学概念叫“理灭绝”，在讨论这一话题之前，我们先来说说香蒜沙司（pesto）这种食品。

The pharmacological therapy for Parkinson's disease is aimed at replenishing dopamine levels, mimicking dopamine's action, or antagonizing the excitatory effects of cholinergic neurons.

帕金森病的物治疗是为了补充多巴胺水平，模仿多巴胺的作，或对抗胆碱能神经递质的兴奋作神经元。

Dipyridamole is usually given intravenously for a pharmacological cardiac stress test, and the heart's response is observed on an electrocardiogram, or ECG, to diagnose cardiac ischemia.

通常我们会在物心脏负荷试验中静脉给予双嘧达莫，之后在心电图上观察心脏的反应，以此来诊断心肌缺血。

According to the book, it takes on average 3 to 4 months for an alcoholic or alcohol-dependent person to lose their dependence on alcohol through this pharmacological extinction method.

该书称，采“理灭绝”疗法，酗酒或酒精成瘾患者平均只需要 3-4 个月的时间，即可摆脱对酒精的依赖。

Surgery can be done when pharmacological treatment is not effective, and the most common procedure is Nissen fundoplication, where the gastric fundus is wrapped around the lower esophageal sphincter in order to make it tighter.

当物治疗无效时，可以进行手术，最常见的手术方法是Nissen胃底折叠术，指胃底包裹在食管下括约肌周围以使其更紧。