METHODS The paratope mapping of antibodies was determined by competitive inhibition in radioimmunoassay and the sequences of variable regions among the antibodies were compared.

应免疫竞争抑制试验测定抗的配位特异性,并对抗的可变区序列进行比较。

The antigen-binding site, the paratope, of an antibody can be seen as being composed of a central core and a more peripheral area situated at its rim.

抗的抗原结合部位(表位)央核和处于边缘位置外周区。