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Hypomagnesemia interferes with the effects of parathyroid hormone, resulting in hypocalcemia.

镁会状旁腺激的作用,导,也可钾。

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Osmosis-肌骨

Ok, now let's have a quick look at parathyroid hormone.

好,来看甲状旁腺的功能。

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Osmosis-泌尿

This affects the amount of parathyroid hormone that gets released by the parathyroid gland.

从而会影响甲状旁腺释放甲状旁腺激素的量。

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Osmosis-肌骨

If osteoporosis is really advanced, teriparatide, a recombinant parathyroid hormone can be used.

如果骨质疏松十分严重,可以使用特立种重组甲状旁腺激素治疗。

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Osmosis-肌骨

Additionally, parathyroid hormone can boost 1-alpha-hydroxylase activity, which forms more active vitamin D, increasing gut absorption of calcium.

此外,甲状旁腺激素可以增加1-α-羟化酶的活性,从而形成更多有活性的维生素D,增加肠道对的吸收。

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Osmosis-泌尿

It turns out, though, that parathyroid hormone also shuts this down.

不过,事证明甲状旁腺激素也会阻止种反应。

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Osmosis-泌尿

To identify the cause, lab tests are typically done, which includes tests for parathyroid hormone, vitamin D, albumin, phosphorus, and magnesium.

为了确定病因,通常要做验室检查,其中包括甲状旁腺激素、维生素D、白蛋白、磷和镁的检测。

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Osmosis-泌尿

Now, that calcium's still in the lumen, but parathyroid hormone also affects the distal convoluted tubule and increases calcium reabsorption.

然在腔内,但甲状旁腺激素也会影响远曲小管,增加对的再吸收。

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Osmosis-肌骨

Lastly, parathyroid hormone increases calcium reabsorption and reduces the reabsorption of phosphate from the kidneys, so more phosphate is excreted through the urine.

最后,甲状旁腺激素可以促进肾脏对的重吸收,而减少对磷酸盐的重吸收,因此导致尿磷升高。

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Osmosis-肌骨

Now, the levels of calcium and phosphate in the bone, but also in the blood, are regulated by vitamin D and parathyroid hormone, or PTH.

和磷不仅存在于骨中,也存在于血液中,磷含量的调节受维生素D和甲状旁腺激素(PTH)调控。

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Osmosis-泌尿

As calcium levels in the blood fall, parathyroid hormone is released, causing the bones to lose calcium.

随着血降低,甲状旁腺激素释放,导致溶骨作用。

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Osmosis-泌尿

Less calcium entering the blood is the most common cause and can be due to hypoparathyroidism, or lower levels or lower activity of parathyroid hormone.

离子进入血液的量减少是最常见的原因,可能是由于甲状旁腺功能减退或者甲状旁腺激素的量或者活性降低。

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Osmosis-泌尿

Related to this is pseudohyporparathyroidism, which is where the kidneys simply don't respond to parathyroid hormone because of a genetic defect in the parathyroid hormone receptor.

与此相关的是伪甲状旁腺功能减退症,也就是由于甲状旁腺激素受体的基因缺陷,肾脏不对甲状旁腺激素作出反应。

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Osmosis-肌骨

Parathyroid hormone is produced by the parathyroid glands in response to low serum calcium, and it increases bone resorption to release calcium into the bloodstream.

顾名思义,甲状旁腺激素在甲状旁腺产生,来应对血清中过低的水平,从而增加骨质的吸收来释放更多的进入血液。

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Osmosis-泌尿

Now, that calcium's still in the lumen, though, but parathyroid hormone also affects the distal convoluted tubule and increases calcium reabsorption.

现在,然在腔内,但是甲状旁腺激素也会影响远曲小管增加的再吸收。

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Osmosis-泌尿

Also, people with the genetic disease DiGeorge syndrome, often born with parathyroid glands that are too small and can't produce enough parathyroid hormone.

或是由于患有DiGeorge综合症,生来甲状旁腺就太小,不能产生足够的甲状旁腺激素。

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Osmosis-肌骨

Now, even though parathyroid hormone stimulates bone resorption, it's been found that intermittent injections with teriparatide activates osteoblasts more than osteoclasts, therefore increasing bone formation.

,即使甲状旁腺激素刺激骨吸收,研究发现间歇性注射特立激活了更多造骨细胞而非破骨细胞,从而增强骨生长。

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Osmosis-泌尿

This can result in conditions like primary hyperparathyroidism which result in too much parathyroid hormone, which leads to excess phosphate being excreted in the urine.

可能引发原发性甲状旁腺功能亢进,会造成甲状旁腺激素过多,导致过多的磷酸盐从尿液中排出。

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Osmosis-肌骨

Parathyroid hormone is secreted in response to low blood calcium levels, and it stimulates the resorption of calcium and a small amount of phosphate from the bone and into the bloodstream.

在血降低,甲状旁腺激素分泌增加,刺激的重吸收,并且使一小部分磷酸盐从骨中入血。

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Osmosis-泌尿

If calcium levels fall, the four parathyroid glands buried within the thyroid gland release parathyroid hormone which frees up both calcium and phosphate ions from the bones.

如果水平下降,那么在甲状腺内的四个甲状旁腺释放甲状旁腺激素,导致骨骼中释放和磷酸盐离子。

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Osmosis-肌骨

Bone remodelling as a whole is highly dependent on serum calcium levels, which, in turn, are kept in the normal range by a balance between parathyroid hormone, or PTH, calcitonin and vitamin D.

整个骨重建进程高度依赖于血清中的含量,而将血清中的含量维持在正常值范围内是由甲状旁腺激素、降血素与维生素D间的制约平衡所控制的。

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