It receives dopaminergic innervations from ventral tegment area and SNc, and noradrenergic and serotonergic innervations from the locus ceruleus (LC) and dorsal raphe nucleus (DRN), respectively.

内侧前额叶皮层主要接受侧被盖区（ventral tegmental area，VTA）和SNcDA能神经纤维，及蓝斑去甲肾上腺素（noradrenaline，NA）能和中缝背核5-HT能神经纤维。