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Altenusin was reported as myosin light chain kinase inhibitor and sphingomyelinase inhibitor.TAN-420E has antitumor activity.

TAN-420E曾报道有抗性,易氧化为Herbimycin A,者是很好的,并具有一定抗菌性。

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Dorothy Dix, dorp, dorr, dorrclone, dorsa, dorsabdominal, dorsad, dorsal, dorsal fin, dorsalchord,

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Crash Course 解剖生理学篇

Specifically, that club-headed myosin wants to get all up-close-and-personal with the actin.

具体来说,棒状头想近距离接触

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TED演讲(视频版) 2022年4月合集

Like the actin and myosin in our muscles that enable us to move.

就像我肉中的一样,它使我能够移动。

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Actin and myosin, the proteins of muscles, permit those bodies to move around.

肉的质, 允许这些身体四处移动。

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Crash Course 解剖生理学篇

They've got their own famous coupling — a pretty pair of tiny protein strands called actin and myosin.

有自己著名的联结——一对漂亮的微小质链,叫做

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Crash Course 解剖生理学篇

But the only myosin heads that can bind to those newly exposed sites are ones that are ready for action.

但是唯一能与这些新露的部位结合的头是那些准备好行动的。

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Crash Course 解剖生理学篇

Then comes a brief period of contraction, when the myosin heads are binding, and pulling, and releasing, over and over, and the muscle fibers contract.

然后是短暂的收缩,这时头一遍又一遍地结合、拉动和释放,肉纤维收缩。

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Crash Course 解剖生理学篇

They're divided lengthwise into segments called sarcomeres, which contain two even tinier strands of protein — two different kinds of myofilaments called actin and myosin.

向上被分成称为节的部分,其中包含两股更小的质——两种不同的丝称为

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Crash Course 解剖生理学篇

At this point, the myosin is totally stoked, because the bodyguards that have been frustrating it are in for a big, irresistible distraction.

这一点上,完全兴奋起来,因为一直让它沮丧的保镖会有一个巨大的、不可抗拒的分心。

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Crash Course 解剖生理学篇

A sarcomere contains both thin filaments, made up mostly of two light and twisty actin strands, and thick filaments, composed of thicker, lumpy-looking myosin strands.

节既包含细丝,主要由两条轻盈而扭曲的链组成,也包含粗丝,由更厚、看起来块状的链组成。

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Crash Course 解剖生理学篇

When those channels are thrown open, the calcium stored inside rushes into the rest of the cell, and finally myosin is like, YES! Here we go!

当这些通道打开时,储存其中的钙会涌入细胞的其余部分,最后就像,是的!开始了!

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Crash Course 解剖生理学篇

So after all that, with the myosin primed for action and the bodyguards out of the way, the myosin finally binds to actin, and it is beautiful.

经过这一切,当准备好行动,保镖离开,最终与结合,这真是太美了。

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Crash Course 解剖生理学篇

That tension means myosin and the calcium pumps are burning up the muscle cells' ATP, and the finite supply of ATP is what makes it impossible to maintain vigorous muscle activity indefinitely.

这种张力意味着和钙泵正燃烧肉细胞的三磷酸腺苷,而三磷酸腺苷的有限供应使得肉活动不可能无限期地保持旺盛。

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Crash Course 解剖生理学篇

But soon the fiber slides back down into the relaxation period, when the calcium gets pumped back into the sarcoplasmic reticulum, and the actin and myosin stop the binding cycle, and the muscle relaxes.

但很快,纤维滑回松弛期,此时钙被泵入浆网,停止结合循环,肉放松。

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Crash Course 解剖生理学篇

If another action potential travels down before that can happen, even more calcium gets released, which ends up exposing more actin for myosin to bind to, and that means more force in that fiber.

如果另一个动作电位此之前下降,更多的钙被释放出来,最终露出更多的来结合,这意味着纤维中有更多的力量。

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Crash Course 解剖生理学篇

You'd also re-learn that your skeletal muscles are constructed like a rope made of bundles of protein fibers, and that the smallest strands are your actin and myosin myofilaments.

你还会重新了解到你的骨骼就像一根由成束质纤维组成的绳子,最小的链是你的丝。

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Crash Course 解剖生理学篇

That binding causes another shape change. But this time, it causes the myosin to release from the actin, in a tear-jerking scene like some microscopic re-creation of the finale from Titanic.

这种结合导致了另一种形状变化。但这一次,它导致中释放出来,这是一个催人泪下的场景,就像泰坦尼克号结局的微观再现。

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Crash Course 解剖生理学篇

Because this is when the myosin breaks down its new molecule of ATP into ADP and a phosphate, which moves it into the armed position yet again, getting it ready for its next rendezvous.

因为这是将其新的 ATP 分子分解成 ADP 和磷酸盐的时候,这使它再次处于武装状态,为下一次会合做好准备。

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Crash Course 解剖生理学篇

When they bind, the myosin releases all that stored energy, and — in the excitement of it all — the myosin changes shape. It pulls on its precious actin strand, kind of like pulling a rope hand over fist.

当它结合时,释放所有储存的能量,兴奋中,改变形状。它拉着它珍贵的链,有点像用手握住拳头拉绳子。

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Crash Course 解剖生理学篇

So the calcium latches on to the troponin and causes it to pull the other bodyguard protein — the tropomyosin — away from the sites on the actin strands that the myosin really wants to get its paws on.

所以钙锁住,并使其将另一种保护——原——从真正想要抓住的链上的位置拉走。

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Crash Course 解剖生理学篇

When a myosin head does that, it moves into an extended position, kinda like a stretched spring — still holding on to the ADP and phosphate, and still storing the energy that was released when they were broken apart.

头这样做时,它会移动到伸展的位置,有点像被拉伸的弹簧——仍然抓住 ADP 和磷酸盐,仍然储存它破裂时释放的能量。

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