This reparable strategy is based on such concepts that the failing myocyte accompanied with intrinsic defects in structure and function could be improved biologically .
And this is due to mutations in the TSC1 or TSC2 tumor suppressor genes, genes that usually suppress tumor growth, therefore a mutation leads to myocyte overgrowth.
However because calcium is also involved in cardiac myocyte contraction, these agents also reduce contractility of the heart and should not be used in case of systolic heart failures.