For example, if the testicles are castrated, or removed for some reason, the prostate significantly shrinks in size, largely due to death of the luminal cells.
Prostate adenocarcinoma most often results from a genetic mutation in a luminal cell, but can also be a basal cell, and it results in that cell dividing uncontrollably.
So, the abnormally high levels of luminal sodium and chloride disrupt the osmotic balance between the intestines and surrounding tissue; and water, bicarbonate, and potassium rush into the lumen of the intestines as a result.
In addition to this, because less sodium is in the distal tubule, less of it moves through the luminal sodium channel into the principal cell and gets pumped over to the other side by the basolateral sodium-potassium pump.