The results indicate that ultrasound alone could initiate lipid peroxidation and lecithoid configuration degradation resulting in membrane fluidity decline.
Mismatches between myocardial fatty acid uptake and utilization lead to the accumulation of cardiotoxic lipid species,and cause lipotoxic cardiomyopathy.
Moreover, increased breakdown of arachidonic acid results in increased production of proinflammatory lipid mediators like prosta glandines, thromboxanes and leukotrienes.
Membrane lipid microdomain is a newly discovered membrane confined domain which consists of sphingomyelin, choles terol , glycosphingolipid and many GPI anchored proteins.
OBJECTIVE To prepare long-circulating nanostructrued lipid carries (NLC) containing hydroxycamptothecin with monostearin and investigate the in vitro and in vivo characterization of them.