4.Novel oncogene with kinase-domain (NOK) can activate multiple mitogenic signaling pathways including the janus kinases (JAK) and signal transducer and activator of transcription proteins (STAT).
5.Uridine-cytidine kinase (UCK) (EC 2.7.1.48) is a pyrimidine ribonucleoside kinase that catalyzes the phosphorylation of uridine and cytidine to UMP and CMP.
5.The most common type is Non-Homologous End Joining where a protein complex called DNA protein kinase begins by binding to each end of the broken DNA.
7.When Rhabdomyolysis develops, the laboratory workup can show elevated levels of creatine kinase and myoglobin, while urinalysis can show tea-colored urine due to high levels of myoglobin.
8.Laboratory results on hospital days 3 and 5 (illness days 7 and 9) reflected leukopenia, mild thrombocytopenia, and elevated levels of creatine kinase (Table 1).
9.Over time, cellular proteins like creatine kinase, or CK, start escaping the damaged cell and calcium starts to enter the cell, and this ultimately leads to cell death.
10.Same goes for indirect muscle recovery markers, like creatine kinase and muscle voluntary isometric force contraction, where active cooldowns don't seem to change much of these recovery factors.
11.Mechanisms of AR to MET-TKIs include MET kinase domain mutations and high levels of amplification of the MET exon 14-mutant allele in up to 35% of cases.
AR 至 MET-TKI 机制包括 MET 激酶构域突变和高达 35% 病例中 MET 外显 14 突变等位基因高水平扩增。机翻
12.See, phorbols mimic the action of diacylglycerol — a fatty molecule your body uses in a number of ways, including to activate an enzyme called protein kinase C, or PKC for short.
13.At this point in the episode I was expecting to be talking about cancer vaccines or kinase inhibitors or immunotherapy - something that I keep hearing about in the news.
14.ROS1 rearrangement ROS1 rearrangements lead to fusions of the ROS1 tyrosine kinase domain (on chromosome 6) with partner genes, usually on other chromosomes, and occur in approximately 2% of NSCLCs.