It can also be prepared by reaction of bromochloromethane with sodium thiocyanate to obtain chloromethyl thiocyanate, and then it reacts with 2-mercapto-benzothiazole.

另一种2-巯噻唑法是先将溴氯甲与化钠反应生成氯甲酯，然后氯甲酯与2-巯噻唑反应得到噻。