The oxidation,displacement and esterification of aromatic amines,aromatic amides and organic boranes using sodium perborate as oxidizing agent were reviewed.
In the related "amide route" starting from 2-chloroisonicotinic acid, 41 ,a secondary amide directing group was used to facilitate the ortho lithiation of the pyridine 3-position.
A kind of monosubstituted squaric amide ——mono carbamoyl amide of squaric acid 3(MCASAQ) was prepared by the condensation of squaric acid (SQ) with urea or its derivatives in water.
To suppress the interference of amide groups in the amorphous phase,the film was placed in heavy water for 4 weeks for deuteration and the deuteration rate was determined.
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