The synthsis methods of N-sulfuryl substitude hetercycles by the reaction of alkyne with sulfamide catalyzed by diverse transition mentals were reviewed in this paper.
Copper ions are frequently poisonous to biological systems.So Dr Bertozzi decided to work on a way to make azides and alkynes react without their involvement.
Her solution, which she published in 2004, was to include the alkyne half of the buckle in a molecule that would put it under strain and thus make it more reactive.