Pyridazinone derivatives have considerable kinds of biological activities such as those cardiotonic,platelet aggregation inhibitory,anti-inflammatory,aldose reductase inhibitory,antifungal and so on.

哒酮类化合物具有多种重要的生物活性,根据作用机的不同,可分为钙增敏剂、磷酸二酯酶抑剂、环氧合酶抑剂等,并可用于相关疾病的治疗。

The synthesis of epalrestat,an aldose reductase inhibitor, was improved. The yield of its intermediate 3-carboxymethyl rhodanine was raised to 76.4%.

对醛搪还原酶抑剂依帕司他的合成工艺作了改进，使中间体绕丹宁乙酸的高到76．4％。

Transketolase is the key enzyme of pentose-phophate pathway, catalyses transfer of a two-carbon fragment from a ketolase (donor substance) to an aldose (acceptor substance).

摘要转酮醇酶是磷酸戊糖途径的关键酶，催化二碳单元在酮糖（供体）和醛糖（受体）间的转移。