Method The target compound was synthesized from clarithromycin via hydrolyzation,acetylation,cyclic carbonatation,oxidation,decarbonatation,acylation,cyclic carbamatation and cyclization.

方法霉素为起始原料,经水解、乙酰化、环碳酯化、氧化、脱碳酯化、酰化、环氨基甲酯化和环等反应成目标化。

The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other,which are histone transacetylase and histone deacetylase.

蛋白乙酰化和去乙酰化由一对功能相互拮抗的蛋白酶——蛋白乙酰基转移酶和蛋白去乙酰化酶负责。