Glutamate binds to NMDA receptors which tell the cell to open up calcium ions channels.

谷氨酸与NMDA，细胞钙离通道打开。

Cytokines are thought to also enhances the activity of the NMDA receptors.

这些细胞因可能NMDA的活性增强。

Now, let's move onto our next drug class that is NMDA receptor antagonist.

现在，让我们进入下一个药物类别，NMDA拮抗剂。

So, NMDA receptors belong to the family of ionotropic glutamate receptors, which mediate most of the excitatory synaptic transmission in the brain.

因此，NMDA属于离型谷氨酸家族，它介导大脑中大部分的兴奋性突触传递。

To address this potential problem, scientists developed NMDA receptor antagonist called Memantine, which works by blocking NMDA receptors and thus limiting calcium influx into the neuron.

为了解决这个潜在的问题，科学家开发了一种叫做NMDA拮抗剂美金刚，它通过阻断NMDA而限制钙进入大脑神经元。

So when glutamate levels become abnormally elevated, overstimulation of NMDA receptors can result, leading to excessive influx of calcium, ultimately causing cell to rapture and die.

所以当谷氨酸水平异常升高时，NMDA的过度刺激会导致过量的钙离流入，最终导致细胞分裂然后死去。

Now, as you may know, the binding of glutamate to the NMDA receptor results in an influx of extracellular calcium, which controls membrane excitability and synaptic transmission.

现在，如你所知，谷氨酸与NMDA的导致内流细胞外钙，控制膜的兴奋性和突触传递。

Its mechanism of action is poorly understood, however, some of the speculated ones are that it prevents dopamine reuptake, facilitates presynaptic dopamine release, and blocks glutamate NMDA receptors.

然而，人们对其作用机制知之甚少，其中一些推测是它能阻止多巴胺再摄取，促进突触前多巴胺释放，并阻断谷氨酸盐NMDA。